Morphological Characteristics of Ruptured Brain Aneurysms: A Systematic Literature Review and Meta‐Analysis

Background It is unclear what morphological features of brain aneurysms are better at predicting risk rupture. We conducted a meta‐analysis to analyze the best determinants rupture status. Methods The Nested Knowledge platform was used perform search articles reporting on aneurysm size, aspect ratio (AR), size (SR), ellipticity index, nonsphericity and undulation index. mean differences between ruptured unruptured were calculate effect sizes. Results A total 63 studies with 13 025 included: 6966 6059 aneurysms. Ruptured had larger ( P <0.001), AR SR index =0.049), =0.049) compared 6.1 mm (95% CI, 5.6–6.5). similar in anterior cerebral artery =0.28), communicating =0.31), basilar =0.51). 1.5 1.4–1.6), 2.3 2.1–2.5). For mirror aneurysms, 1.2 1.2–1.5), 2.2 Conclusions Size not significantly different located artery, artery. all locations. thresholds associated